Media inquiries

Sara Green
(617) 233-1714

A New Approach to Treating Multiple Sclerosis


SARM1 the Central Driver of Axonal Degeneration

cADPR and NF-L are SARM1-Dependent Biomarkers of Axonal Structure and Function that Enable Therapeutic Discovery and Clinical Translation
Krauss R, Engber T, Hughes R, Bosanac T, Devraj R
Presented at the Molecular Mechanisms of Axon Degeneration Meeting. 2019 March 11

SARM1 Deletion Prevents Degeneration of Peripheral and Central Axons
Krauss R, Engber T, Devraj R, Bosanac T, Hughes R
Presented at the Neuroscience 2018 conference. 2018 November 3

Development of SARM1 Inhibitors to Treat Peripheral Neuropathies
Hughes R, Devraj R, Engber T, Bosanac T, Krauss R
Presented at the 2018 Peripheral Nerve Society Annual Meeting. 2018 July 23

Sarm1 Deletion, but Not WldS, Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy
Gilley J, Ribchester R, Coleman M
Cell Rep. 2017 Oct 3;21(1):10-16

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD+ Cleavage Activity that Promotes Pathological Axonal Degeneration
Essuman K, Summers DW, Sasaki Y, Mao X, DiAntonio A, Milbrandt J
Neuron. 2017 Mar 22;93(6):1334-1343

SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation
Summers DW, Gibson DA, DiAntonio A, Milbrandt J
Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6271-E6280

Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism
Gerdts J, Summers DW, Milbrandt J, DiAntonio A
Neuron. 2016 Feb 3;89(3):449-60

SARM1 activation triggers axon degeneration locally via NAD⁺ destruction
Gerdts J, Brace EJ, Sasaki Y, DiAntonio A, Milbrandt J
Science. 2015 Apr 24;348(6233):453-7

Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons
Summers DW, DiAntonio A, Milbrandt J
J Neurosci. 2014 Jul 9;34(28):9338-50

Sarm1-mediated axon degeneration requires both SAM and TIR interactions
Gerdts J, Summers DW, Sasaki Y, DiAntonio A, Milbrandt J
J Neurosci. 2013 Aug 14;33(33):13569-80

Measuring Axonal Degeneration

Neurofilaments as biomarkers in neurological disorders
Khalil M, Teunissen CE, Otto M, Piehl F, Sormani MP, Gattringer M, Barro C, Kappos L, Comabella M, Fazekas F, Petzold A, Blennow K, Zetterberg H, Kuhle J
Nature Reviews Neurology (2018)

Neurofilament light chain as disease biomarker in a rodent model of chemotherapy induced peripheral neuropathy
Meregalli C, Fumagalli G, Alberti P, Canta A, Carozzi VI, Chiorazzi A, Monza L, Pozzi E, Sandelius Å, Blennow K, Zetterberg H, Marmiroli P, Cavaletti G
Experimental Neurology, Volume 307, September 2018, Pages 129-132

Serum neurofilament as a predictor of disease worsening and brain and spinal cord atrophy in multiple sclerosis
Barro C, Benkert P, Disanto G, Tsagkas C, Amann M, Naegelin Y, Leppert D, Gobbi C, Granziera C, Yaldizli Ö, Michalak Z, Wuerfel J, Kappos L, Parmar K, Kuhle J
Brain, Volume 141, Issue 8, 1 August 2018, Pages 2382–2391

Peripheral blood neurofilament light chain levels: the neurologist’s C-reactive protein?
Giovannoni G, MBBCh, PhD
Brain, Volume 141, Issue 8, 1 August 2018, Pages 2235–2237

Neurofilament light chain: A prognostic biomarker in amyotrophic lateral sclerosis
Lu CH, Macdonald-Wallis C, Gray E, Pearce N, Petzold A, Norgren N, Giovannoni G, Fratta P, Sidle K, Fish M, Orrell R, Howard R, Talbot K, Greensmith L, Kuhle J, Turner MR, Malaspina A
Neurology. 2015 Jun 2; 84(22): 2247–225

Neurofilaments and 10-year follow-up in multiple sclerosis
Bhan A, Jacobsen C, Myhr KM, Dalen I, Lode K, Farbu E
Multiple Sclerosis Journal 2018 Aug 1

Plasma neurofilament light chain concentration in the inherited peripheral neuropathies
Sandelius A, Zetterberg H, Blennow K, Adiutori R, Malaspina A, Laura M, Reilly MM, Rossor AM
Neurology 2018;90:e518-e524. doi:10.1212/WNL.0000000000004932

Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington’s disease: a retrospective cohort analysis
Byrne LM, Rodrigues FB, Blennow K, Durr A, Leavitt BR, Roos RAC, Scahill RI, Tabrizi SJ, Zetterberg H, Langbehn D, Wild EJ
Lancet Neurol 2017; 16: 601–09

Serum Neurofilament Light: A Biomarker of Neuronal Damage in Multiple Sclerosis
Disanto G, Barro C, Benkert P, Naegelin Y, Schädelin S, Giardiello A, Zecca C, Blennow K, Zetterberg H Leppert D, Kappos L, Gobbi, C, Kuhle J, and the Swiss Multiple Sclerosis Cohort Study Group
ANN NEUROL 2017;81:857–870

Blood-based NfL – A biomarker for differential diagnosis of parkinsonian disorder
Hansson O, Janelidze S, Hall S. Magdalinou N, Lees AJ, Andreasson U, Norgren N, Linder J, Forsgren, Constantinescu R, Zetterberg H, Blennow K
Neurology, February 8, 2017, DOI